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李 萌
2010-04-14 09:09   发布范围:公开

李萌,女,博士,第四军医大学药学系生物制药学教研室讲师。2000年毕业于陕西师范大学生命科学学院,2003年获得陕西师范大学生命科学学院细胞生物学硕士学位,2006年获得第四军医大学生物化学与分子生物学专业博士学位。20082010年于美国密西根大学医学院消化内科学系从事博士后研究。从事的主要科学研究包括:肿瘤标志物的筛选与鉴定,肿瘤靶向治疗及肿瘤疫苗的研究。目前,承担国家自然科学基金一项(?),曾参与国家自然科学基金两项(No.39870240; No.30270383),共发表科研论文 11篇(第一作者6篇)。获得中国国家专利一项(ZL200510096370.0),美国国家专利一项(申请号:61/170,614)。

 

发表论文:

1Li M, Qin X, Xue X, Zhang C, Yan Z, Han W, Komarck C, Wang TD, Zhang Y. Safety evaluation and pharmacokinetics of a novel human tumor necrosis factor-alpha exhibited a higher antitumor activity and a lower systemic toxicity. Anticancer Drugs. 2010 Mar;21(3):243-51.

2Li M, Wang TD. Targeted endoscopic imaging. Gastrointest Endosc Clin N Am. 2009 Apr;19(2):283-98.

3. Li M, Han W, Zhang Q, Xue X, Wang Z, Zhang Y. Development of a mimotope-based vaccine against CD20 antigen. Protein Pept Lett. 2007;14(6):610-4.

4. Li M, Yan Z, Han W, Zhang Y. Mimotope vaccination for epitope-specific induction of anti-CD20 antibodies. Cell Immunol. 2006 Feb;239(2):136-43. Epub 2006 Jun 30.

5.Qin X, Wan Y, Li M, Xue X, Wu S, Zhang C, You Y, Wang W,  Identification of a novel peptide ligand of human vascular endothelia growth factor receptor 3 for targeted tumor diagnosis and therapy. J Biochem. 2007 Jul;142(1):79-85. Epub 2007 May 21.

6.Wan Y, Xue X, Li M, Zhang X, Qin X, Zhang C, You Y, Wang W, Jiang C, Wu S, Liu Y, Zhu W, Ran Y, Zhang Z, Han W, Zhang Y.  Prepared and screened a modified TNF-alpha molecule as TNF-alpha autovaccine to treat LPS induced endotoxic shock and TNF-alpha induced cachexia in mouse. Cell Immunol. 2007 Jun 23; [Epub ahead of print]

7. Quanhong L, Shihui S, Yaping X, Hao Q, Jinxuan Z, Yaohui R, Meng Li, Pan W. Synergistic anti-tumor effect of ultrasound and hematoporphyrin on sarcoma180 cells,with special reference to the changes of morphology and   cytochrome  oxidase activity of tumor cells J.Exp.Clin.Cancer Res., 2004 232):333341.

8. Meng Li, Quanhong Liu, Hao Qi, Jinxuan Zhang, Kun Zhang, Pan Wang. The scanning electron microscope observation of two kinds cancer cells treated by ultrasound irritating HpD. Journal of Northwest University. 2003 Apr.33(2):223-226.

9. Meng Li, Yongmei Zhao, Pan Wang. A Preliminary Report on the killing Effect of Ultrasound and Hematoporphyrin on Ehrlick Ascites Tumor in Vivo. Journal of Xi’An United University. 2003 Apr.6(2):9-12.

10. Quanhong Liu, Pan Wang, Meng Li, Hao Qi, Zhiyuan Shang, Yaohui Ren, Kun Zhang, Xiao Yao. Apopotosis of Ehrlich ascites tumor cells by sonochemical activated hematoporphyrin. Acta Zoologica Sinica. 2003 49(5):620-628.

10.Quanhong Liu, Shihui Sun, Yaping Xiao, Hao Qi, Zhiyuan Shang, Junping Zhang, Meng Li, Qing Li. Study of cell killing and morphology on S180 by ultrasound activating hematoporphyrin derivatives. Science In China (Series C).2003 Jun.46(3):253-262.

11. Kun Zhang, Hao Qi, Quanhong Liu, Qing Li, Meng Li. Effects of hematoporphyrin activated with lower intensity focus ultrasound on SW2480 cells measured by MTT colorimetric assay. Journal of Shaanxi Normal University. 2003 31(1):93-98.

 

 

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